Megadeth es una de las bandas estadounidenses de thrash metal más famosas de la historia. Fue creada en 1983, después de que Mustaine fuera expulsado de Metallica, donde ocupaba el puesto de guitarrista. Ha figurado varias veces en el top 10 de las listas del Billboard y ha vendido más de 20 millones de álbumes en todo el mundo, incluyendo cinco álbumes de platino consecutivos y siete nominaciones consecutivas al Grammy en la categoría de Mejor Interpretación de Metal. A través de sus 25 años en activo, Megadeth ha tenido 18 miembros oficiales, siendo Mustaine el único miembro permanente y el principal compositor.
Killing Is My Business... And Business Is Good!1. Last Rites/Loved To Death
2. Killing Is My Business... And Business Is Good!
3. The Scull Beneath The Skin
4. The Boots
5. Rattle Head
6. Chosen Ones
7. Looking Down The Cross
8. Mechanix
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Peace Sells... But Who's Buying?1. Wake Up Dead
2. The Conjuring
3. Peace Sells
4. Devil's Island
5. Good Mourning / Black Friday
6. Bad Omen
7. I Ain't Superstitious
8. My Last Words
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So Far, So Good... So What!1. Into The Lungs Of Hell
2. Set The World A Fire
3. Anarchy In The U.K.
4. Mary Jane
5. 502
6. In My Darkest Hour
7. Liar
8. Hook In Mouth
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Rust in Peace1. Holy Wars...The Punishment Due
2. Hangar 18
3. Take No Prisoners
4. Five Magics
5. Poison Was The Cure
6. Lucretia
7. Tornado Of Souls
8. Dawn Patrol
9. Rust In Peace...Polaris
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Countdown to Extinction1. Skin O'my Teeth
2. Symphony Of Destruction
3. Architecture Of Aggression
4. Foreclosure Of A Dream
5. Sweating Bullets
6. This Was My Life
7. Countdown To Extinction
8. High Speed Dirt
9. Psychotron
10. Captive Honour
11. Ashes In Your Mouth
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Youthanasia1. Reckoning Day
2. Train Of Consequences
3. Addicted To Chaos
4. À Tout Le Monde
5. Elysian Fields
6. The Killing Road
7. Blood Of Heroes
8. Family Tree
9. Youthanasia
10. I Thought I Knew It All
11. Black Curtains
12. Victory
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Hidden Treasures1. No More Mr. Nice Guy
2. Breakpoint
3. Go To Hell
4. Angry Again
5. 99 Ways To Die
6. Paranoid
7. Diadems
8. Problems
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Cryptic Writings1. Trust
2. Almost Honest
3. Use The Man
4. Mastermind
5. The Disintegrators
6. I'll Get Even
7. Sin
8. A Secret Place
9. Have Cool, Will Travel
10. She-Wolf
11. Vortex
12. F.F.F
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Risk1. Insomnia
2. Prince of Darkness
3. Enter the Arena
4. Crush 'Em
5. Breadline
6. The Doctor Is Calling
7. I'll Be There
8. Wanderlust
9. Ecstasy
10. Seven
11. Time: The Beginning
12. Time: The End
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The World Needs a Hero1. Disconnect
2. The World Needs A Hero
3. Moto Psycho
4. 1000 Times Goodbye
5. Burning Bridges
6. Promises
7. Recipe For Hate... Warhorse
8. Losing My Senses
9. Dread And The Fugitive Mind
10. Silent Scorn
11. Return To Hangar
12. When
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The System Has Failed1. Blackmail The Universe
2. Die Dead Enough
3. Kick The Chair
4. The Scorpion
5. Tears In A Vial
6. I Know Jack
7. Back In The Day
8. Something That I'm Not
9. Truth Be Told
10. Of Mice And Men
11. Shadow Of Deth
12. My Kingdom Come
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United Abominations1. Sleepwalker
2. Washington Is Next
3. Never Walk Alone
4. United Abominations
5. Gears Of War
6. Blessed Are The Dead
7. Play For Blood
8. A Tout Le Monde (Set Me Free)
9. Amerikhastan
10. You're Dead
11. Burnt Ice
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Estos solo son los álbumes de estudio.